Fire is one of the greatest threats to museums and other cultural properties. Safeguarding these institutions and their collections requires fire suppression systems in addition to effective fire prevention measures. This presentation will provide an overview of the various types of fire suppression systems appropriate for cultural properties, including wet, dry and pre-action sprinkler systems, as well as water mist, total flooding clean agent, and hypoxic air systems. We will look at their benefits and drawbacks, as well as the practical application for small and mid-sized institutions of these systems in the museum environment.